A-Bec (Abacavir) is a nucleoside analogue that inhibits HIV reverse transcriptase and selectively suppresses the replication of HIV-1 and HIV-2, including HIV-1 strains resistant to zidovudine, lamivudine, zalcitabine, didanosine and nevirapine.
Abacavir undergoes intracellular metabolism, transforming into the active form carbovir-5′-triphosphate (carbovir-TF). According to in vitro studies, the antiviral effect of the drug is due to the inhibition of HIV reverse transcriptase, which leads to the interruption of DNA synthesis on the viral RNA matrix and the arrest of HIV replication.
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