Emduo (Stavudine & Lamivudine) the drug belongs to the group of combined drugs – direct antiviral agents, nucleoside and nucleotide reverse transcriptase inhibitors, antiviral agents based on lamivudine and stavudine.
Stavudine is a thymidine analog. It is phosphorylated by cellular kinases into active triphosphate. Stavudine triphosphate inhibits HIV reverse transcriptase by competing with a natural substrate, thymidine triphosphate. This leads to the termination of DNA replication.
Lamivudine (Lamivudine, 3TC) is a nucleoside reverse transcriptase inhibitor (NRTI), antiviral agent used in combination antiretroviral therapy, active against HIV and hepatitis B.