Emtri (Lamivudine Nevirapine & Stavudine) is an antiviral combination. The use of drugs in combination slows down the development of viral resistance to zidovudine.
Zidovudine
A synthetic analogue of thymidine, under the action of cellular kinases, is phosphorylated into zidovudine monophosphate, and then, under the influence of host cell enzymes, it is converted into di- and triphosphate, which, due to competition with deoxythymidine triphosphate, suppresses the replication of the human immunodeficiency virus by inhibiting HIV reverse transcriptase. This disrupts the synthesis of mRNA and, accordingly, virus proteins.
Lamivudine
A synthetic analogue of thymidine, under the action of cellular kinases, is phosphorylated into 5-phosphate, which, due to competition with deoxythymidine triphosphate, suppresses the replication of the human immunodeficiency virus by inhibiting HIV reverse transcriptase. This disrupts the synthesis of mRNA and, accordingly, virus proteins. It is active against the hepatitis B virus.
Nevirapine
Non-nucleoside inhibitor of HIV-1 reverse transcriptase, directly binds to reverse transcriptase, blocks RNA and DNA-dependent activity of DNA polymerase, as a result of which it causes the destruction of the catalytic center of the enzyme. Inactive against HIV-2 reverse transcriptase and human α, β, γ and s polymerases.
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