VagaCyte (Valganciclovir) – antiviral agent, ganciclovir L-valyl ester. It is a prodrug of ganciclovir. After oral administration, it is rapidly transformed into ganciclovir with the participation of intestinal and liver esterases.
Ganciclovir is a synthetic analogue of guanine. Inside the cell, ganciclovir is sequentially metabolized into the monophosphate form with the participation of cellular deoxyguanosine kinase, then into the active ganciclovir triphosphate. Acting as a substrate and incorporating into DNA, ganciclovir triphosphate competitively inhibits viral DNA synthesis. This leads to suppression of DNA synthesis by inhibiting DNA strand elongation. Ganciclovir inhibits viral DNA polymerase more actively than cellular polymerase.
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