Zidine (Zidovudine) is a synthetic analogue of nucleosides. Inside the cell, zidovudine is phosphorylated to an active metabolite, zidovudine-5-triphosphate. Zidovudine triphosphate inhibits HIV reverse transcriptase by interrupting viral DNA synthesis after incorporation into the nucleotide chain. Zidovudine triphosphate weakly inhibits cellular DNA polymerases alpha and gamma.
In combination with other antiviral HIV drugs, it increases the number of CD4 cells.